- November 12, 2013
Methionine AminoPeptidase (MAP) are enzymes that catalyze the removal of the N-terminal methionine from the nascent chain at the ribose. The N-terminal methionine is removed co-translationally when the chains are less than 40 amino acids. HsMetAP1 pulls down L26, which is located near the exit tunnel of the nascent polypeptide. In addition, HsMetAP1 also pulls down the whole nascent polypeptide-associated complex (NAC), and NAC is known to bind directly to L25.
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